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Paroxetin

Klassificering: 2

Preparat: Arketis, Euplix, Paroxetin 2care4, Paroxetin Actavis, Paroxetin Alpharma, Paroxetin Amneal, Paroxetin Aurobindo, Paroxetin Ebb, Paroxetin EQL Pharma, Paroxetin Hexal, Paroxetin HEXAL, Paroxetin Mylan, Paroxetin Orifarm, Paroxetin Orion, Paroxetin ratiopharm, Paroxetin Sandoz, Paroxetin Teva, Paroxiflex, Seroxat, Seroxat®

ATC kod: N06AB05

Substanser: paroxetin, paroxetinhydroklorid (vattenfri), paroxetinhydrokloridhemihydrat, paroxetinmesilat

Råd till allmänheten

Kontakta läkare för diskussion innan behandling påbörjas.

För hälso- och sjukvården

Rekommendation

Risken för ett friskt fullgånget barn anses vara låg vid terapeutiska doser.

Bakgrund

Passerar över till bröstmjölk. Baserat på data från >100 kvinnor kan den relativa barndosen beräknas till max 6 % (1-10, 21-23). Plasmakoncentrationer av paroxetin har varit icke-detekterbara eller mycket låga hos ca 50 ammade barn (2, 5-6, 8, 11-12). Inga negativa effekter har rapporterats hos ca 165 ammade barn (4-5, 7-11,13-17, 24, 26). Följande symtom har sammanlagt rapporterats hos 24 ammade barn: sen utveckling, rastlöshet, agitation, svårmatat, vakenhet, förstoppning, sömnighet, elektrolytrubbning och irritabilitet (10, 14-15, 18-20, 24-26).

Uppdaterat: 2019-05-17

Referenser

Dokumentationsgrad: 2
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- Författat av Klinisk farmakologi, Karolinska Universitetssjukhuset för Hälso- och sjukvårdsförvaltningen, Stockholms läns landsting. Janusmed amning uppdateras kvartalsvis.