Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal

Drugline nr 20992

Publicerat 2004-02-27

Question

Which hypnotic drug is preferred during lactation?

A 35-year-old woman is breast-feeding her 10-day-old child. Her physician requests advice on a suitable hypnotic drug.

Answer

Zopiclone is a cyclopyrrolone hypnotic which have effects similar to that of benzodiazepines. It has a comparative short elimination half-life of about 5 hours (1). The estimated relative weight-adjusted dose is about 4.0 per cent. The suckling infant would receive an absolute dose of about 5.0 micrograms per kilo per day. Adverse reactions were not observed in the suckling child. Sedative adverse reactions in a suckling child seem unlikely but cannot be excluded (1).

Exposure may be further reduced by: Administering the drug just after a feed, administering the drug before the longest sleeping period of the child and pumping out breast milk (if possible) just before the drug is administered and use this for the first upcoming feed after drug intake.

Conclusion

Zopiclone may be used as a hypnotic during lactation. The suckling child would receive a very small amount of drug, and sedative adverse reactions in the suckling child seem unlikely, but cannot be excluded.

Exposure may be further reduced by: administering the drug just after a feed, administering the drug before the longest sleeping period of the child and pumping out breast milk (if possible) just before the drug is administered and use this for the first upcoming feed after drug intake.

The mother should be advised about possible, although unlikely, adverse reactions in the child.

Damkier P
Brosen K

References

  1. Bennett PN (ed), Drugs and human lactation. 2nd ed. Amsterdam: Elsevier; 1996. p. 515-6.

Senast ändrad 2018-09-20