Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal

Furosemid

Klassificering: A

Preparat: Diural, Frusol, Furix Retard, Furix®, Furosemid AB Unimedic, Furosemid Accord, Furosemid Copyfarm, Furosemid Hexal, Furosemid Meda, Furosemid Orifarm, Furosemid Recip, Furosemid Teva, Impugan®, Lasilix Retard, Lasix Retard, Lasix®, Lasix® Retard

ATC kod: C03CA01

Substanser: furosemid

Sammanfattning

Den vätskedrivande effekten av furosemid är likvärdig för kvinnor och män.
 

Additional information

Pharmacokinetics and dosing

The renal clearance of furosemide after intravenous administration in older healthy men (60-70 years of age) has been shown to be lower than in younger healthy men (20-35 years of age). No information of clearance in women was reported [1]. No studies with a clinically relevant sex analysis regarding the dosing of furosemide have been found.

Effects

Diuretic response to oral (80 mg) and intravenous (40 mg over 2 min) furosemide was measured in healthy volunteers (6 men, 6 women) in a randomized, cross-over study. No clinically relevant sex differences in diuretic response, urine flow rate, potassium excretion rate and natriuretic response were found [2].

Adverse effects

Associations between loop diuretics and fracture risk have been reported. In a population-based case-control register study (89 255 men, 169 555 women), all prescriptions for loop diuretics were identified among fracture cases and control redeemed within 5 years before the date of hospitalization of cases. Men and women taking loop diuretics had a similar pattern on risk of fracture [3].

Reproductive health issues

Regarding teratogenic aspects, please consult the Drugs and Birth Defects Database (in Swedish, Janusmed fosterpåverkan).

Other information

A randomized clinical trial (620 men, 239 women) investigated the effects of low-dose furosemide (20 mg slow injection) on contrast-induced nephropathy (CIN). The incidence of CIN in furosemide-treated females was higher compared with men (8.5% vs. 7.9%). For both sexes, the incidence in the control group was higher compared with the furosemide group [4].

Försäljning på recept

Fler kvinnor än män hämtade ut läkemedel innehållande furosemid (ATC-kod C03CA01) på recept i Sverige år 2018, totalt 170 545 kvinnor och 130 957 män. Det motsvarar 34 respektive 26 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 85 år och äldre hos båda könen. I genomsnitt var läkemedel innehållande furosemid 1,5 gånger vanligare hos kvinnor [5].

Uppdaterat: 2019-05-27

Litteratursökningsdatum: 2019-03-06

Referenser

  1. Lasix (furosemide). DailyMed [www]. US National Library of Medicine. [updated 2018-05-31, cited 2019-03-06]. länk
  2. Franson KL, Kuk JM, Lam NP, Lau AH. Gender effect on diuretic response to hydrochlorothiazide and furosemide. Int J Clin Pharmacol Ther. 1996;34:101-5. PubMed
  3. Rejnmark L, Vestergaard P, Mosekilde L. Fracture risk in patients treated with loop diuretics. J Intern Med. 2006;259:117-24. PubMed
  4. Gu GQ, Lu R, Cui W, Liu F, Zhang Y, Yang XH et al. Low-dose furosemide administered with adequate hydration reduces contrast-induced nephropathy in patients undergoing coronary angiography. Cardiology. 2013;125:69-73. PubMed
  5. Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2018 [cited 2019-03-08.] länk

Författare: Linnéa Karlsson Lind

Faktagranskat av: Mia von Euler

Godkänt av: Karin Schenck-Gustafsson