ATC kod: A10BB07
Vissa studier indikerar att kvinnor har högre risk att få hypoglykemi vid antidiabetikabehandling än män. Det saknas publicerade kontrollerade studier för glipizid om skillnader i dosering och behandling mellan kvinnor och män.
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of glipizide have been found.
No studies with a clinically relevant sex analysis regarding the effects of glipizide have been found.
The ACCORD study (Action to Control Cardiovascular Risk in Diabetes) was a randomized, controlled trial designed to test the effect of intensive glucose control compared with standard control on cardiovascular outcomes in patients with type 2 diabetes. The study showed that women had a higher risk of hypoglycemia than men regardless of treatment in general [1].The risk of hypoglycemia in patients treated with a combination of metformin and glipizide or sitagliptin was evaluated in a German study (694 men, 478 women). In patients treated with metformin and glipizide, more women experienced confirmed or severe hypoglycemia than men [2]. The frequency of hypoglycemia events was investigated in patients 66 years or older using sulfonylureas, i.e. glipizide or glibenclamide (also called glyburide). The participants also filled a prescription for one of the 16 most commonly prescribed antimicrobials for this population (n=44,991 male prescriptions, n=88,544 female prescriptions). There was no significant interaction between patient sex on the odds of subsequent hypoglycemia [3].
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Fler män än kvinnor hämtade ut tabletter innehållande glipzid (ATC-kod A10BB07) på recept i Sverige år 2019, totalt 9 010 män och 5 802 kvinnor. Det motsvarar 1,8 respektive 1,1 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 70 år och äldre hos båda könen. I genomsnitt var tabletter innehållande glipzid 1,6 gånger vanligare hos män [4]. Detta speglar könsskillnaden i prevalens av typ 2-diabetes [5].
Uppdaterat: 2020-10-06
Litteratursökningsdatum: 2020-07-09
Faktagranskat av: Carl-Olav Stiller
Godkänt av: Karin Schenck-Gustafsson