ATC kod: C03BA04
Effekten av klortalidon avseende minskat blodtryck, sjuklighet och dödlighet har visats vara likvärdig mellan kvinnor och män. Uppgifter om farmakokinetiska könsskillnader saknas.
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of chlorthalidone have been found.
A subgroup analysis of the large ALLHAT study (17 719 men, 15 638 women) showed similar mortality and morbidity rates in men and women taking chlorthalidone [1].
Results from the SHEP Pilot Study (248 men, 303 women) showed that blood pressure response to chlorthalidone 25-50 mg/day was similar in men and women [2].
In a Canadian study comparing effectiveness and safety of chlorthalidone and hydrochlorothiazide in older hypertensive adults (4 224 men and 6 160 women on chlorthalidone; 7 984 men and 11 505 women on hydrochlorothiazide), no significant sex difference in incidence rate of events per 100 person-years was observed [3].
Regarding teratogenic aspects, please consult the Drugs and Birth Defects Database (in Swedish, Janusmed fosterpåverkan).
The effects of long-term chlorthalidone use on bone-related biochemical variables in elderly patients who had participated in the SHEP program were studied (36 men, 30 women). In both men and women, chlorthalidone use was associated with a decreased serum iPTH (immunoreactive parathyroid hormone) and serum osteocalcin. Vitamin D (measured as 25OHD) levels were lower in women than in men, but were not affected by actual drug therapy [5].
Nästan lika många män och kvinnor hämtade ut tabletter innehållande klortalidon (ATC-kod C03BA04) på recept i Sverige år 2018, totalt 860 män och 758 kvinnor [5].
Uppdaterat: 2019-04-17
Litteratursökningsdatum: 2019-03-11
Faktagranskat av: Mia von Euler
Godkänt av: Karin Schenck-Gustafsson