Lymecyklin
Klassificering: BATC kod: J01AA04
Sammanfattning
Det saknas kontrollerade studier om skillnader mellan könen avseende effekt, säkerhet och farmakokinetik för lymecyklin.
Kunskapsunderlaget avseende skillnader mellan kvinnor och män är mycket begränsat och motiverar inte olika dosering eller behandling.
Additional information
Pharmacokinetics and dosing
No studies with a clinically relevant sex analysis regarding pharmacokinetics or dosing of lymecycline have been found [6]. In general, transdermal absorption seems to be similar in men and women [7].
Effects
No studies with a clinically relevant sex analysis regarding effect of lymecycline have been found.
Adverse effects
No studies with a clinically relevant sex analysis regarding adverse effects of lymecycline have been found.
Reproductive health issues
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Other information
Lymecycline is a tetracycline used for systemic treatment of acne. Tetracyclines can be incorporated in growing bones and teeth and lymecycline is therefore not recommended for use in children younger than 12 years and in pregnant or breastfeeding women [8].Acne is very common in teenagers, affecting 80-90% to some degree [1]. In a study of volunteers above the age of 25 years (322 men, 427 women) clinical facial acne was recorded in 3% and 12% of men and women, respectively [2].
A prospective study of quality of life and choice of therapy in acne (143 females, 68 males) found the quality of life to improve after treatment at a group level. Women had a lower quality of life score not correlated to severity of acne at start of the study. After six months of treatment with acne preparations the quality of life score correlated to clinical grading and also to treatment with isoretinoin [3].
Age and sex-matched acne patients (270 men, 270 women) with a mean age of 20 years had their skin pH measured, showing the pH of the female face to be slightly higher than that of the male one. Skin pH is affected by age, anatomical site, genetic factors, sebum, skin moisture, sweat, detergents, cosmetics, soaps, washing patterns, and occlusive dressing [4].
Healthy volunteers (30 men, 30 women) were studied to determined influencing factors for facial pores. Factors increasing pores were male sex, increased sebum and decreased skin elasticity [5].
Försäljning på recept
Fler kvinnor än män hämtade ut kapslar innehållande lymecyklin (ATC-kod J01AA04) på recept i Sverige år 2015, totalt 31 327 kvinnor och 21 514 män. Det motsvarar 6,4 respektive 4,4 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 15-19 år hos båda könen. I genomsnitt var kapslar innehållande lymecyklin 1,5 gånger vanligare hos kvinnor [9].
Uppdaterat: 2020-08-28
Litteratursökningsdatum: 2016-06-15
Referenser
- Lello J, Pearl A, Arroll B, Yallop J, Birchall NM. Prevalence of acne vulgaris in Auckland senior high school students. N Z Med J. 1995;108:287-9. PubMed
- Goulden V, Stables GI, Cunliffe WJ. Prevalence of facial acne in adults. J Am Acad Dermatol. 1999;41:577-80. PubMed
- Berg M, Lindberg M. Possible gender differences in the quality of life and choice of therapy in acne. J Eur Acad Dermatol Venereol. 2011;25:969-72. PubMed
- Youn SH, Choi CW, Choi JW, Youn SW. The skin surface pH and its different influence on the development of acne lesion according to gender and age. Skin Res Technol. 2013;19:131-6. PubMed
- Kim BY, Choi JW, Park KC, Youn SW. Sebum, acne, skin elasticity, and gender difference - which is the major influencing factor for facial pores?. Skin Res Technol. 2013;19:e45-53. PubMed
- Agwuh KN, MacGowan A. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother 2006 Aug;58(2):256-65 PubMed
- Schwartz JB. The influence of sex on pharmacokinetics. Clin Pharmacokinet. 2003;42:107-21. PubMed
- Sánchez AR, Rogers RS, Sheridan PJ. Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity. Int J Dermatol. 2004;43:709-15. PubMed
Faktagranskat av: Mia von Euler
Godkänt av: Karin Schenck-Gustafsson