ATC kod: D06BB04
En studie visade bättre effekt vid egenbehandling av kondylom hos män, men den kliniska relevansen är oklar.
Kunskapsunderlaget avseende skillnader mellan kvinnor och män är begränsat och motiverar inte olika dosering eller behandling.
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of podophyllotoxin have been found. No difference between men and women has been shown for transdermal absorption in general [1].
The efficacy and safety of self-applied 0.5% podophyllotoxin solution has been compared with hospital-applied 25% podophyllin solution for external condylomata acuminata (anogenital warts) (138 men, 67 women). Besides the observation of the superiority of podophyllotoxin, it was also observed that the effect of podophyllotoxin treatment in men was generally superior to that achieved in women; wart clearance was observed in 53% of men and 37% of women after one week and in 86% of men and 72% of women at 5 weeks of podophyllotoxin treatment. However, a higher proportion of podophyllotoxin-treated women had been treated previously for warts, thus possibly indicating a more treatment resistant population. According to the authors, the observed sex difference may relate to the greater easiness of self-applied therapy in men or biological difference in the speed of response to treatment [2].
No studies with a clinically relevant sex analysis regarding adverse effects of podophyllotoxin have been found.
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Fler män än kvinnor hämtade ut läkemedel innehållande podofyllotoxin (ATC-kod D06BB04) på recept i Sverige år 2015, totalt 6 313 män och 3 121 kvinnor. Det motsvarar 1,3 respektive 0,6 personer per tusen invånare. Andelen som hämtat ut läkemedel var högst i åldersgruppen 25-29 år hos båda könen. I genomsnitt var läkemedel innehållande podofyllotoxin 2,0 gånger vanligare bland män [3].
Uppdaterat: 2020-08-28
Litteratursökningsdatum: 2016-01-17
Faktagranskat av: Mia von Euler
Godkänt av: Karin Schenck-Gustafsson