Drug products: Amorolfin ABECE, Amorolfin Apofri, Amorolfin Evolan, Amorolfin Mylan, Amorolfine Teva, Finail, Loceryl, Loceryl Creme, Loceryl®
ATC code: D01AE16
Substances: amorolfine, amorolfine hydrochloride
Published controlled studies on differences between men and women regarding the effect, safety and pharmacokinetics of amorolfine are lacking.
The present evidence concerning differences between men and women is very limited and do not motivate differentiation in dosing or treatment.
Amorolfine is approved for topical use in the treatment of fungal infections in toe- and finger nails. It is not marketed in North America.
Amorolfine is administered topically as a nail laquer and the systemic uptake is very small . No studies on sex differences in pharmacokinetic properties have been identified.
No studies with a clinically relevant sex analysis regarding effects of amorolfine have been found.
No studies with a clinically relevant sex analysis regarding adverse effects of amorolfine have been found.
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
In a review of the epidemiology of onychomyosis the sex distribution was found to vary considerably between different studies and populations but the conclusion was that most studies showed male preponderance .
Date of litterature search: 2016-12-17
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson