Drug products: Finacea, Finacea®, Skinoren®
ATC code: D10AX03
Substances: azelaic acid
Controlled studies on differences between men and women regarding efficacy, safety and pharmacokinetics of topical azelaic acid are lacking.
The present evidence concerning differences between men and women is limited and do not motivate differentiation in dosing or treatment.
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of azelaic acid have been found.
Both male and female patients have been included in studies of the effect of azelaic acid in acne vulgaris or rosacea. However, relevant sex analysis has not been found. Analysis of published data from a small study on periorificial dermatitis (4 boys, 6 girls) did not show any sex difference in effect .
No studies with a clinically relevant sex analysis regarding the dosing of azelaic acid have been found.
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Date of litterature search: 2015-12-21
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson