Benzylpenicillin
Classification: BATC code: J01CE01, J01CE08, J01CR50
Summary
Controlled studies on differences between men and women regarding safety and pharmacokinetics of benzylpenicillin are lacking. A cohort study has shown an higher serological cure of syphilis in men than in women following treatment with benzylpenicillin.
Additional information
Pharmacokinetics and dosing
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of benzylpenicillin have been found.
Effects
A register-based cohort study including 1327 patients with syphilis (782 men, 545 women) showed higher serological cure in men than in women, following treatment with benzylpenicillin [1].
Adverse effects
No studies with a clinically relevant sex analysis regarding adverse effects of benzylpenicillin have been found.
Reproductive health issues
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Updated: 2021-02-12
Date of litterature search: 2021-01-11
References
- Tong ML, Lin LR, Liu GL, Zhang HL, Zeng YL, Zheng WH et al. Factors associated with serological cure and the serofast state of HIV-negative patients with primary, secondary, latent, and tertiary syphilis. PLoS One. 2013;8(7):e70102. PubMed
- Concise (INSIKT). Kalmar: eHälsomyndigheten. 2018 [cited 2019-03-14.] länk
Reviewed by: Diana Rydberg
Approved by: Karin Schenck-Gustafsson