Drug products: Bensylpenicillin® Meda, BENZETACIL 1.200.000, Benzylpenicillin Panpharma, Bicillin C-R 900/300, Lentocilin S 1200, Pendysin, PFIZERPEN, Tardocillin, Tardocillin 1200
ATC code: J01CE01, J01CE08, J01CR50
Substances: benzylpenicillin, benzylpenicillin potassium, benzylpenicillin sodium, benzylpenicillin, procaine
Controlled studies on differences between men and women regarding safety and pharmacokinetics of benzylpenicillin are lacking. A cohort study has shown an higher serological cure of syphilis in men than in women following treatment with benzylpenicillin.
Pharmacokinetics and dosing
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of benzylpenicillin have been found.
A register-based cohort study including 1327 patients with syphilis (782 men, 545 women) showed higher serological cure in men than in women, following treatment with benzylpenicillin .
No studies with a clinically relevant sex analysis regarding adverse effects of benzylpenicillin have been found.
Reproductive health issues
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Date of litterature search: 2021-01-11
- Tong ML, Lin LR, Liu GL, Zhang HL, Zeng YL, Zheng WH et al. Factors associated with serological cure and the serofast state of HIV-negative patients with primary, secondary, latent, and tertiary syphilis. PLoS One. 2013;8(7):e70102. PubMed
- Concise (INSIKT). Kalmar: eHälsomyndigheten. 2018 [cited 2019-03-14.] länk
Reviewed by: Diana Rydberg
Approved by: Karin Schenck-Gustafsson