Drug products: Cefadroxil 500 TS - 1 A Pharma, Cefadroxil Mylan, Cefadroxil Sandoz, Cefamox löslig, Cefamox®, Cefamox® löslig, Grüncef
ATC code: J01DB05
Substances: cefadroxil, cefadroxil monohydrate
Large controlled studies on differences between men and women regarding efficacy, safety and pharmacokinetics of cefadroxil are lacking.
The present evidence concerning differences between men and women is limited and do not motivate differentiation in dosing or treatment.
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of cefadroxil have been found.
In a trial with a three-day oral treatment with cefadroxil 1 g daily in elderly patients with bacteriuri (2 men and 11 women on cefadroxil) only two women had negative urine cultures . The clinical significance of this is uncertain.
Resistance patterns for pathogens often differ between populations. A study in Swedish children (494 boys, 512 girls; <2 years old) between the years 1994-2003 found that the resistance to cefadroxil in the entire population by E. coli was very low (<1%) while enterococci showed total resistance .
No studies with a clinically relevant sex analysis regarding adverse effects of cefadroxil have been found.
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Date of litterature search: 2016-02-24
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson