Drug products: Cefadroxil 500 TS - 1 A Pharma, Cefadroxil Mylan, Cefadroxil Sandoz, Cefamox löslig, Cefamox®, Cefamox® löslig, Grüncef
ATC code: J01DB05
Substances: cefadroxil, cefadroxil monohydrate
Large controlled studies on differences between men and women regarding efficacy, safety and pharmacokinetics of cefadroxil are lacking.
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of cefadroxil have been found.
In a trial with a three-day oral treatment with cefadroxil 1 g daily in elderly patients with bacteriuri (2 men and 11 women on cefadroxil) only two women had negative urine cultures . The clinical significance of this is uncertain.
Resistance patterns for pathogens often differ between populations. A study in Swedish children (494 boys, 512 girls; <2 years old) between the years 1994-2003 found that the resistance to cefadroxil in the entire population by E. coli was very low (<1%) while enterococci showed total resistance .
No studies with a clinically relevant sex analysis regarding adverse effects of cefadroxil have been found.
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Date of litterature search: 2016-02-24
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson