Cefadroxil
Classification: BATC code: J01DB05
Summary
Large controlled studies on differences between men and women regarding efficacy, safety and pharmacokinetics of cefadroxil are lacking.
Additional information
Pharmacokinetics and dosing
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of cefadroxil have been found.
Effects
In a trial with a three-day oral treatment with cefadroxil 1 g daily in elderly patients with bacteriuri (2 men and 11 women on cefadroxil) only two women had negative urine cultures [1]. The clinical significance of this is uncertain.
Resistance patterns for pathogens often differ between populations. A study in Swedish children (494 boys, 512 girls; <2 years old) between the years 1994-2003 found that the resistance to cefadroxil in the entire population by E. coli was very low (<1%) while enterococci showed total resistance [2].
Adverse effects
No studies with a clinically relevant sex analysis regarding adverse effects of cefadroxil have been found.
Reproductive health issues
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Updated: 2020-08-28
Date of litterature search: 2016-02-24
References
- Tzias V, Dontas AS, Petrikkos G, Papapetropoulou M, Dracopoulos J, Giamarellou H. Three-day antibiotic therapy in bacteriuria of old age. J Antimicrob Chemother. 1990;26:705-11. PubMed
- Swerkersson S, Jodal U, Åhrén C, Hansson S. Urinary tract infection in small outpatient children: the influence of age and gender on resistance to oral antimicrobials. Eur J Pediatr. 2014;173:1075-81. PubMed
- Socialstyrelsens statistikdatabas . Stockholm: Socialstyrelsen. 2015 [cited 2016-03-14.] Socialstyrelsens statistikdatabas
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson