ATC code: R01AC01, R03BC01, S01GX01
Published controlled studies on differences between men and women regarding pharmacokinetics, dosing and safety of sodium cromoglycate are lacking. The effect of sodium cromoglycate as a treatment for improving tear film break up time was in a small study shown to be better in women.
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of sodium cromoglycate have been found.
In a randomized study of sodium cromoglycate’s prolonging effect of tear film break up time in patients with an [abnormal tear film break-up] acute tear film break up phenomenon (13 men, 28 women) men had a lower increase in mean tear film break up time than women (39% vs 83%) [1]. Women have been shown to have a higher concentration of magnesium ions in their tear fluid [2]. A hypothesis to explain the better effect is that magnesium ions in tear fluid induce gelling of sodium cromoglycate thus creating a protective film [1].
No studies with a clinically relevant sex analysis regarding the adverse effects of sodium cromoglycate have been found.
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Updated: 2020-08-28
Date of litterature search: 2015-10-21
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson