Drug products: Flucloxacillin, Flucloxacillin Orion, Flucloxacillin Sandoz, Flukloxacillin Athlone, Flukloxacillin Meda, Heracillin, Heracillin®
ATC code: J01CF05
Substances: flucloxacillin, flucloxacillin magnesium, flucloxacillin sodium
Controlled studies on differences between men and women regarding efficacy and pharmacokinetics of pivmecillinam are lacking.
The present evidence concerning differences between men and women is limited and do not motivate differentiation in dosing or treatment.
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of flucloxacillin have been found.
No studies with a clinically relevant sex analysis regarding the effects of flucloxacillin have been found.
Clinical studies have reported a higher incidence of drug-induced liver injury in women with certain drugs such as nitrofurantoin, flucloxacillin, erythromycin and isoniazid . Several retrospective observational studies have reported a female preponderance in flucloxacillin-induced liver injury. However, numbers of reported cases have been small and the differences between men and women have not reached statistical significance. [2-4]. A UK study of flucloxacillin-induced drug-induced liver injury (15 men, 36 women) showed association with HLA-B*5701 genotype .
Regarding teratogenic aspects, please consult the Drugs and Birth Defects Database (in Swedish, Janusmed fosterpåverkan).
Date of litterature search: 2016-02-03
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson