Drug products: Flucloxacillin, Flucloxacillin Orion, Flucloxacillin Sandoz, Flukloxacillin Athlone, Flukloxacillin Meda, Heracillin, Heracillin®
ATC code: J01CF05
Substances: flucloxacillin, flucloxacillin magnesium, flucloxacillin sodium
Published controlled studies on differences between men and women regarding efficacy and pharmacokinetics of pivmecillinam are lacking.
No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of flucloxacillin have been found.
No studies with a clinically relevant sex analysis regarding the effects of flucloxacillin have been found.
Clinical studies have reported a higher incidence of drug-induced liver injury in women with certain drugs such as nitrofurantoin, flucloxacillin, erythromycin and isoniazid . Several retrospective observational studies have reported a female preponderance in flucloxacillin-induced liver injury. However, numbers of reported cases have been small and the differences between men and women have not reached statistical significance. [2-4]. A UK study of flucloxacillin-induced drug-induced liver injury (15 men, 36 women) showed association with HLA-B*5701 genotype .
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Date of litterature search: 2016-02-03
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson