Drug products: Amaryl®, Glimepirid 2care4, Glimepirid Actavis, Glimepirid Alternova, Glimepirid Bluefish, Glimepirid Copyfarm, Glimepirid Krka, Glimepirid Mylan, Glimepirid Orion, Glimepirid Sandoz, Glimepirid STADA
ATC code: A10BB12
Glimepiride is used for treatment of type-2 diabetes when lifestyle-modifying treatment has been insufficient.
Controlled studies on differences between men and women in glimepiride efficacy and safety are lacking. Sex differences in glimepiride pharmacokinetics have not been observed.
Some studies indicate that women have a higher risk of hypoglycemia during antidiabetic treatment than men.
The present evidence concerning differences between men and women is limited and do not motivate differentiation in dosing or treatment.
Population pharmacokinetic analyses have found no sex differences in the pharmacokinetics of glimepiride after adjustment for body weight [3,4]. No studies with a clinically relevant sex analysis regarding the dosing of glimepiride have been found.
No studies with a clinically relevant sex analysis regarding the effects of glimepiride have been found.
The ACCORD study (Action to Control Cardiovascular Risk in Diabetes) was a randomized, controlled trial designed to test the effect of intensive glucose control compared with standard control on cardiovascular outcomes in patients with type 2 diabetes. The study showed that women had a higher risk of hypoglycemia than men regardless of treatment .
Regarding teratogenic aspects, please consult the Drugs and Birth Defects Database (in Swedish, Janusmed fosterpåverkan).
An observational retrospective study compared the effects of glimepiride or glibenclamide treatment on body weight over 12 months of treatment in patients with type 2 diabetes. Sex had no significant influence on change in body weight or BMI .
Date of litterature search: 2014-04-28
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson