Drug products: Bifiteral Beutel, Duphalac Frukt, Duphalac®, Lactulose Teva, Laktipex®, Laktulos Alternova, Laktulos Apelsin Meda, Laktulos Levolac, Laktulos Meda, Laktulos MIP, Laktulos Solvay
ATC code: A06AD11
Published controlled studies on differences between men and women in lactulose efficacy and safety are lacking.
Lactulose is a synthetic disaccharide consisting of fructose and galactose, and is used for treatment of obstipation and hepatic encephalopathy.
Pharmacokinetics and dosing
Lactulose is poorly absorbed when administrated orally. No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of lactulose have been found.
No studies with a clinically relevant sex analysis regarding the effects of lactulose have been found.
No studies with a clinically relevant sex analysis regarding adverse effects of lactulose have been found.
Reproductive health issues
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
In a large British registry study (82450 men, 153264 women), the prevalence of constipation was almost twice as high among women up to the age of 75 years, but higher in men than women among patients aged over 75 years. There was no difference between men and women in choice of laxative (macrogol, lactulose, senna or other laxatives including ispaghula). The most commonly prescribed laxative in pregnant patients with constipation were lactulose followed by macrogol .
Date of litterature search: 2015-08-20
- Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-04-05.] länk
- Shafe AC, Lee S, Dalrymple JS, Whorwell PJ. The LUCK study: Laxative Usage in patients with GP-diagnosed Constipation in the UK, within the general population and in pregnancy An epidemiological study using the General Practice Research Database (GPRD). Therap Adv Gastroenterol. 2011;4:343-63. PubMed
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson