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Lactulose

Classification: B

Drug products: Bifiteral Beutel, Duphalac Frukt, Duphalac®, Lactulose Teva, Laktipex®, Laktulos Alternova, Laktulos Apelsin Meda, Laktulos Meda, Laktulos MIP, Laktulos Solvay, Loraga®

ATC code: A06AD11

Substances: lactulose

Summary

Controlled studies on differences between men and women in lactulose efficacy and safety are lacking.
 
The present evidence concerning differences between men and women is limited and do not motivate differentiation in dosing or treatment.

Additional information

Lactulose is a synthetic disaccharide consisting of fructose and galactose, and is used for treatment of obstipation and hepatic encephalopathy.

Pharmacokinetics and dosing

Lactulose is poorly absorbed when administrated orally. No studies with a clinically relevant sex analysis regarding the pharmacokinetics or dosing of lactulose have been found.

Effects

No studies with a clinically relevant sex analysis regarding the effects of lactulose have been found.

Adverse effects

No studies with a clinically relevant sex analysis regarding adverse effects of lactulose have been found.

Reproductive health issues

Regarding teratogenic aspects, please consult the Drugs and Birth Defects Database (in Swedish, Janusmed fosterpåverkan).

Other information

In a large British registry study (82450 men, 153264 women), the prevalence of constipation was almost twice as high among women up to the age of 75 years, but higher in men than women among patients aged over 75 years. There was no difference between men and women in choice of laxative (macrogol, lactulose, senna or other laxatives including ispaghula).  The most commonly prescribed laxative in pregnant patients with constipation were lactulose followed by macrogol [2].

Updated: 2019-02-26

Date of litterature search: 2015-08-20

References

  1. Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-04-05.] länk
  2. Shafe AC, Lee S, Dalrymple JS, Whorwell PJ. The LUCK study: Laxative Usage in patients with GP-diagnosed Constipation in the UK, within the general population and in pregnancy An epidemiological study using the General Practice Research Database (GPRD). Therap Adv Gastroenterol. 2011;4:343-63. PubMed

Authors: Linnéa Karlsson Lind, Desirée Loikas

Reviewed by: Mia von Euler

Approved by: Karin Schenck-Gustafsson