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Classification: A

Drug products: Meronem, Meronem®, Meropenem Bradex, Meropenem FarmaPlus, Meropenem Fresenius Kabi, Meropenem Hexal, Meropenem Mylan, Meropenem Panpharma, Meropenem Pfizer, Meropenem Sandoz, Meropenem STADA, Meropenem SUN, Meropenem-Rotexmedica

ATC code: J01DH02

Substances: meropenem, meropenem trihydrate


Studies have shown that the response to meropenem is similar in men and women.

Additional information

Pharmacokinetics and dosing

A population pharmacokinetic model of meropenem in Japanese adult patients with febrile neutropenia has been developed with patient data from an open-label Phase 3 clinical study (64 men, 34 women). Patients received meropenem 1 g every 8 h for 7-14 days. The volume of distribution was higher in men (13.8 vs. 10.7 L). However, Cmax, Tmax and plasma concentration levels were similar in men and women, despite renal function [2].


In a randomized double-blind trial conducted by the manufacturer, adult patients (in total 1037) with complicated skin and skin structure infections received 500 mg meropenem i.v. every 8 h or 500 mg imipenem-cilastatin IV every 8 h. Percent of patients with satisfactory clinical response at the follow-up visit were similar in men and women receiving meropenem (88% and 84%, respectively) [3].Meropenem (1 g every 8 h) were compared to doripenem (500 mg every 8 h) in a phase 3, randomized, double-blind study including hospitalized adult patients (200 men, 119 women) with complicated intra-abdominal infections. The clinical cure rates were similar in men and women receiving meropenem (85.1% and 85.5%, respectively) [4]. The clinical and bacteriological responses to ceftazidime (1 g every 8 h) versus meropenem (0.5 g every 8 h) were assessed in hospitalized patients (257 men, 152 women) with community-acquired pneumonia, according to risk factors. The responses were similar in men and women in both treatment groups [1].

Adverse effects

No studies with a clinically relevant sex analysis regarding adverse effects of meropenem have been found.

Reproductive health issues

Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).

Updated: 2020-08-28

Date of litterature search: 2016-08-17


  1. Finch RG, Pemberton K, Gildon KM. Pneumonia: the impact of risk factors on the outcome of treatment with meropenem and ceftazidime. J Chemother. 1998;10:35-46. PubMed
  2. Ohata Y, Tomita Y, Nakayama M, Tamura K, Tanigawara Y. Optimal treatment schedule of meropenem for adult patients with febrile neutropenia based on pharmacokinetic-pharmacodynamic analysis. J Infect Chemother. 2011;17:831-41. PubMed
  3. Merrem IV (meropenem). DailyMed [www]. US National Library of Medicine. [updated 2016-07-27, cited 2016-08-17]. länk
  4. Lucasti C, Jasovich A, Umeh O, Jiang J, Kaniga K, Friedland I. Efficacy and tolerability of IV doripenem versus meropenem in adults with complicated intra-abdominal infection: a phase III, prospective, multicenter, randomized, double-blind, noninferiority study. Clin Ther. 2008;30:868-83. PubMed
  5. Concise. Stockholm: eHälsomyndigheten. 2015 [cited 2016-08-22.] länk

Authors: Linnéa Karlsson Lind

Reviewed by: Mia von Euler

Approved by: Karin Schenck-Gustafsson