Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal


Classification: B

Drug products: Avopenin, Fenoximetylpenicillin EQL Pharma, Kåvepenin®, Kåvepenin® Frukt, Peceve®, Primve, Tikacillin

ATC code: J01CE02

Substances: phenoxymethylpenicillin


Controlled studies on differences between men and women regarding the effect, safety and pharmacokinetics of fenoximetylpenicillin are lacking. A smaller study indicates that exposure of fenoximetylpenicillin during pregnancy can be lower than in non-pregnant women, and dose adjustment thus can be needed.
The present evidence concerning differences between men and women is limited and do not motivate differentiation in dosing or treatment.

Additional information

Pharmacokinetics and dosing

A pharmacokinetic study described changes in phenoxymethylpenicillin pharmacokinetics during pregnancy (12 pregnant women, 6 non-pregnant controls), in comparison to non-pregnant circumstances. Following a single dose, half-life was shorter during the third trimester compared to the non-pregnant state. Also, exposure was lower for women in the second trimester of pregnancy than for non-pregnant women. These findings indicate increased elimination of phenoxymethylpenicillin during mid and late pregnancy, although differences in elimination were non-significant. The authors recommend reduced dosing-interval or increased dose of phenoxymethylpenicillin in pregnant women [2].


No studies with a clinically relevant sex analysis regarding the effect of phenoxymethylpenicillin have been found.

Adverse effects

No studies with a clinically relevant sex analysis regarding adverse effects of phenoxymethylpenicillin have been found.

Reproductive health issues

Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).

Other information

A retrospective study, including 1921 patients (794 men, 1122 women, lack of access to 5 medical records), found a greater occurrence of positive penicillin skin test result in female patients than in male patients with self-reported penicillin allergy. The risk was calculated from the whole set of 64 positive results (11 men, 53 women), including different penicillins [1].

Updated: 2020-08-28

Date of litterature search: 2014-12-16


  1. Park MA, Matesic D, Markus PJ, Li JT. Female sex as a risk factor for penicillin allergy. Ann Allergy Asthma Immunol. 2007;99:54-8. PubMed
  2. Heikkilä AM, Erkkola RU. The need for adjustment of dosage regimen of penicillin V during pregnancy. Obstet Gynecol. 1993;81:919-21. PubMed
  3. Läkemedelsstatistik. Stockholm: Socialstyrelsen. 2015 [cited 2016-04-05.] länk

Authors: Anna Garmén, Desirée Loikas

Reviewed by: Mia von Euler

Approved by: Karin Schenck-Gustafsson