Drug products: Protopic, Takrolimus 2care4, Takrolimus Accord, Takrolimus Ebb, Takrozem
ATC code: D11AH01
Substances: tacrolimus, tacrolimus monohydrate
Controlled studies on differences between men and women regarding efficacy, safety and pharmacokinetics of tacrolimus are lacking.
The present evidence concerning differences between men and women is very limited and do not motivate differentiation in dosing or treatment.
No difference between men and women has been shown for transdermal absorption in general .
No studies with a clinically relevant sex analysis regarding effects of tacrolimus have been found.
No studies with a clinically relevant sex analysis regarding adverse effects of tacrolimus have been found.
Regarding teratogenic aspects, please consult Janusmed Drugs and Birth Defects (in Swedish, Janusmed fosterpåverkan).
Date of litterature search: 2017-03-24
Reviewed by: Mia von Euler
Approved by: Karin Schenck-Gustafsson