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Mometasone

Hazard 6 P 3 B 0 T 3 Risk Low

Information

The T-value in the score for hazard refers to acute/chronic toxicity. Underlying data for P, B, T and risk comes from Fass.se.

Fass environmental information

Below is Hazard and Risk from Fass environmental information for Asmanex Twisthaler (mometasone) (downloaded 2018-07-04).

Hazard

Persistence: "DT50 (total system) = 81 to 105 days (OECD 308)." Mometasone is slowly degraded in the environment.

Bioaccumulation: Log Kow: pH 5 = 4.66, pH 7 = 4.68, pH 9 = 4.81. "BCFwhole body, total residues = 104.9 to 107.1. Since BCF < 500, mometasone furoate has low potential for bioaccumulation."

Chronic toxicity: There is NOEC for 3 trophic levels, lowest fish (Pimephales promelas) (OECD 210) NOEC 32d (total length and dry weight) = 0.14 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.42 which gives the risk low.

Author: The Pharmaceutical unit of Region Stockholm