The T-value in the score for hazard refers to acute toxicity. Underlying data for P, B and T comes from Fass.se.
Fass environmental information Riamet (artemether, lumefantrine) for artemether (downloaded 2018-06-26)
Persistence: "8.0 % degradation in 28 days, not readily biodegradable (OECD302C). Artemether does not pass the criteria for ready biodegradation."
Bioaccumulation: Log Pow = 4.4
Acute toxicity: There is data for 3 trophic levels, lowest for algae (Selenastrum capricornutum) 0.33 mg/L.
"Artemether fulfils the screening criteria for a persistent and bioaccumulative substance. Moreover, toxicity to aquatic species has been found in acute toxicity studies. However, as no chronic environmental toxicity data is available no definitive assessment of the T criteria can be made and artemether can therefore not be considered a potential PBT substance."
PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.0000545 which gives the environmental risk insignificant.
Author: The Pharmaceutical unit of Region Stockholm