The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B, T and risk are from Fass.
Fass environmental information for Arcoxia (etoricoxib) (downloaded 2018-09-24).
Persistence: Test OECD 314 and OECD 308. "No study has shown an appreciable degradation of etoricoxib. The phrase “Etoricoxib is potentially persistent” is thus chosen."
Bioaccumulation: Log Kow = 2.3 at pH 7 (OECD 107).
Chronic toxicity: There is NOEC for XX trophic levels, lowest NOEC for crustacean (Daphnia magna) 750 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.001 which gives the risk insignificant.
Comparative assessment of environmental risk when using diclofenac, naproxen, ibuprofen, ketoprofen, etoricoxib, and paracetamol in Sweden.
Log P for diclofenac from PubChem is reported to be 3.9-4.51. Available data clearly indicate that diclofenac represents the highest risk of the NSAID/analgesics investigated. The NSAIDs (ibuprofen, ketoprofen and naproxen) + paracetamol recommended in the Wise List are all better from an environmental point of view than diclofenac. Paracetamol is a very safe alternative from an environmental point of view. The others are also expected to cause a low environmental risk, somewhat elevated to ketoprofen.
Author: The Pharmaceutical unit of Region Stockholm