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Hydrochlorothiazide

Hazard 3 P 3 B 0 T 0 Risk Insignificant

Information

The T-value in the score for hazard refers to acute/chronic toxicity. Underlying data for P, B, T and risk are from Fass.se.

Fass environmental information

Fass environmental information for hydrochlorthiazide from Diovan Comp (hydrochlorthiazide, valsartan) (downloaded 2018-07-06).

Hazard

Persistence: "DT50 (total system) = 34.7 – 37.3 days (OECD 308)."

Bioaccumulation: Log Dow = 0.09 at pH 7 (OECD107).

Chronisk toxicity: There is NOEC for 3 trophic levels, lowest NOEC for fish (Pimephales promelas, fathead minnow) NOEC 30 days "(hatchability, survival, length and weight)" = 10,0 mg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.00042 which gives the risk insignificant.

Author: The Pharmaceutical unit of Region Stockholm