The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B and T are from Fass. Risk comes from Report Goodpoint 2016 and 2018.
Fass environmental information for Ipren (ibuprofen) (downloaded 2018-12-05).
Persistence: "Ibuprofen passes the ready biodegradation test (with uncertainty around the 10-day window criterion due to sampling frequency) and has a DT50 < 32 days in a sediment dissipation study. The phrase “Ibuprofen is degraded in the environment” is thus chosen."
Bioaccumulation: "BCF in rainbow trout (Oncorhynchus mykiss) after 8-d exposure with 3 μg/L ibuprofen = 1.50 (muscle) and 23.69 (fat). Zhang et al., (2010). Maximum BCF in rainbow trout (Oncorhynchus mykiss) muscle after an 8-day exposure to 2.79 mg/L ibuprofen = 6.6 Togunde et al. (2012). Maximum BCF in fathead minnow (Pimephales promelas) tissue after 28 d exposure and 14 d depuration (OECD 305), and in channel catfish (Ictalurus punctatus) after 7 d exposure and 7 d depuration with 250 μg/L ibuprofen = 1.4. Nallani et al. (2011)."
Toxicity: There are data for 3 trophic levels, most sensitive green algae NOEC, Pseudokirchneriella subcapitata (formerly Selenastrum capricornutum), 10 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2015. PEC / PNEC = 2.95 which gives the risk moderate.
In Sweden, ibuprofen has been measured in surface waters and in fish. In fish in concentrations far below therapeutic levels (Report Goodpoint 2016) .
Ibuprofen has been detected in treated wastewater, and surface water Stockholm County during the years 2012-2016.
Comparative assessment of environmental risk when using diclofenac, naproxen, ibuprofen, ketoprofen, etoricoxib, and paracetamol in Sweden (Report Goodpoint 2018): Log P for diclofenac from PubChem is reported to be 3.9-4.51. Available data clearly indicate that diclofenac represents the highest risk of the NSAID/analgesics investigated. The NSAIDs (ibuprofen, ketoprofen and naproxen) + paracetamol recommended in the Wise List are all better from an environmental point of view than diclofenac. Paracetamol is a very safe alternative from an environmental point of view. The others are also expected to cause a low environmental risk, somewhat elevated to ketoprofen.
Author: The Pharmaceutical unit of Region Stockholm