Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal

Macrogol

Hazard 0 P 0 B 0 T 0 Risk Insignificant

Information

The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B, T and risk are from Fass.

Fass environmental information

Fass environmental information for Movicol (potassium chloride, macrogol, sodium chloride, sodium bicarbonate) (downloaded 2019-02-07).

Hazard

Persistence: "Mixtures containing PEG 3350 were 10% of the theoretical maximum after 4 days, 60% after 7 days and 96% at the end of the test (Day 28). Substances are considered to be readily biodegradable in this test if CO2 production is equal to or greater than 60% of the theoretical value within ten days of the level achieving 10%. [---] The phrase “Macrogol 3350 (PEG 3350) is degraded in the environment” is thus chosen."

Bioaccumulation: Log10 Kow of PEG 3350 (macrogkol 3350) was <1.0.

Toxicity: There are data for 3 trophic levels, most sensitive crustacean (Daphnia magna) NOEC 9 500 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.09 which gives the risk insignificant.

Author: The Pharmaceutical unit of Region Stockholm