Based on the ability to bind to the androgen receptor, bind to SHBG (Sex Hormone Binding Globulin) and studies on fish make medroxyprogesterone a much lower environmental risk than levonorgestrel and norethisterone. The ability of a substance to activate the androgen receptor in fish probably contributes to increased risk of environmental impact, and binding to SHBG is believed to contribute to increased bioconcentration (and thus potency) in fish.
Manufacturers have on fass.se indicated that there is a lack of environmental information of the substance. It is voluntary for manufacturers to provide information on the environmental impact.
Author: The Pharmaceutical unit of Region Stockholm