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Terbinafine

Hazard 6 P 0 B 3 T 3 Risk Moderate

Information

The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B and T comes from Fass.se.

Fass environmental information

Fass environmental information for Lamisil Dermgel (terbinafine) (downloaded 2018-07-02).

Hazard

Persistence: "Degradation - DT50 (freshwater phase) = 3-8 days DT50 (total system) = 16-31 days. The DT50 32 days therefore the phrase ‘The substance is degraded in the environment’ is chosen."

Bioaccumulation: "Partition Coefficient: log Kow 5.2 (22.0 °C, OECD107). BCF calculated: 5248"

Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC for green algae (Pseudokirchneriella subspicata) 0.53 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 1.62 which gives the risk moderate.

Author: The Pharmaceutical unit of Region Stockholm