Fludarabine
Summary
Persistence. It cannot be excluded that fludarabine phosphate is persistent, as data are lacking.
Bioaccumulation. Fludarabine phosphate has low potential for bioaccumulation.
Toxicity. It cannot be excluded that fludarabine phosphate is toxic, as data are lacking.
Risk. Environmental risk from fludarabine phosphate cannot be excluded due to a lack of ecotoxicological data.
The dephosphorylated product fludarabine (2F-ara-A) is the principal metabolite present in the systemic circulation. This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Fludara (fludarabine phosphate) from Sanofi AB (retrieved on 2025-07-01).
Hazard
Persistence: No data.
Bioaccumulation: Log P = -1.18 at 7 (estimated data, method unknown).
Toxicity: No data.
Risk
PEC = 0.0000209 microg/L (sales data for Sweden for the year 2022). Environmental risk from fludarabine phosphate cannot be excluded due to a lack of ecotoxicological data.
References
Author: Health and Medical Care Administration, Region Stockholm
