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Gadobutrol

Summary

Persistence. Gadobutrol anhydrous is potentially persistent.

Bioaccumulation. Gadobutrol anhydrous has low potential for bioaccumulation.

Toxicity. Gadobutrol has low chronic toxicity. For comments on this, see under the heading Detailed information.

Risk. The use of gadobutrol (sales data Sweden 2021) has been considered to result in insignificant environmental risk.

 

This summary information comes from fass.se.

Detailed information

Fass environmental information

Fass environmental information for Gadovist (gadobutrol) from Bayer (retrieved on 2025-06-30).

Hazard

Persistence: Gadobutrol is neither readily biodegradable in the aquatic environment (only 4% degradation over 28 days) nor susceptible to hydrolysis, according to studies conducted in line with FDA guidelines. These properties justify its classification as potentially persistent in the environment.

Bioaccumulation: Log Dow = -5.4 at 7.

Toxicity: There are data for 3 trophic levels, most sensitive fish and crustacean NOEC ≥ 1000 microg/L. Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.

Risk

PEC/PNEC is based on sales data in Sweden in year 2021. PEC/PNEC = 0.000097 wich gives the risk insignificant.

References

  1. Fass för vårdpersonal.

Author: Health and Medical Care Administration, Region Stockholm