Gå till innehåll

Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal

Gadoxetic acid

Summary

Persistence. Gadoxetic acid is potentially persistent.

Bioaccumulation. Gadoxetic acid has low potential for bioaccumulation.

Toxicity. Gadoxetic acid has low acute toxicity. See comment under Detailed Information.

Risk. The use of gadoxetic acid (sales data Sweden 2021) has been considered to result in insignificant environmental risk.

 

This summary information comes from fass.se.

Detailed information

Fass environmental information

Fass environmental information for Primovist (gadoxetic acid) from Bayer (retrieved on 2025-07-07).

Hazard

Persistence: Degradation of Gadoxetic Acid Gadoxetic acid showed 0% biodegradation over 28 days in an OECD 301E test using municipal sewage sludge, despite the test being valid and non-toxic to microbes. It was also found to be stable at pH 5, 7, and 9, indicating resistance to hydrolysis. Based on these results, gadoxetic acid is not readily biodegradable and resistant to abiotic degradation, justifying the classification “potentially persistent.”

Bioaccumulation: The log Dow was reported with -4.9 at 7. Guideline OECD 107.

Acute toxicity: There are data for 3 trophic levels, most sensitive crustacean (Daphnia magna) EC50 ≥ 100 mg/L. Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.

Risk

PEC/PNEC is based on sales data in Sweden in year 2021. PEC/PNEC = 0.000021 which gives the risk insignificant.

Author: Health and Medical Care Administration, Region Stockholm