Gadoxetic acid
Summary
Persistence. Gadoxetic acid is potentially persistent.
Bioaccumulation. Gadoxetic acid has low potential for bioaccumulation.
Toxicity. Gadoxetic acid has low acute toxicity. See comment under Detailed Information.
Risk. The use of gadoxetic acid (sales data Sweden 2021) has been considered to result in insignificant environmental risk.
This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Primovist (gadoxetic acid) from Bayer (retrieved on 2025-07-07).
Hazard
Persistence: Degradation of Gadoxetic Acid Gadoxetic acid showed 0% biodegradation over 28 days in an OECD 301E test using municipal sewage sludge, despite the test being valid and non-toxic to microbes. It was also found to be stable at pH 5, 7, and 9, indicating resistance to hydrolysis. Based on these results, gadoxetic acid is not readily biodegradable and resistant to abiotic degradation, justifying the classification “potentially persistent.”
Bioaccumulation: The log Dow was reported with -4.9 at 7. Guideline OECD 107.
Acute toxicity: There are data for 3 trophic levels, most sensitive crustacean (Daphnia magna) EC50 ≥ 100 mg/L. Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.
Risk
PEC/PNEC is based on sales data in Sweden in year 2021. PEC/PNEC = 0.000021 which gives the risk insignificant.
References
Author: Health and Medical Care Administration, Region Stockholm