Iodixanol

Summary

Persistence. Iodixanol is potentially persistent.

Bioaccumulation. Iodixanol has low potential for bioaccumulation.

Toxicity. Iodixanol has low acute toxicity.

Risk. The use of iodixanol (sales data Sweden 2019) has been considered to result in insignificant environmental risk.

This summary information comes from fass.se.

Detailed information

Fass environmental information

Fass environmental information for Visipaque (iodixanol) from GE Healthcare (retrieved on 2025-07-09).

Hazard

Persistence: Iodixanol showed low degradation in a 28-day test (OECD 301), with only 2% DOC (Dissolved Organic Carbon) removal and low BOD (Biochemical Oxygen Demand). According to OECD criteria, at least 70% DOC removal within 28 days is required to be classified as readily biodegradable. Conclusion: The substance is potentially persistent.

Bioaccumulation: Iodixanol has a very low log P_ow value (–4.05), indicating a low potential for bioaccumulation.

Acute toxicity: There are data for 3 trophic levels, most sensitive fish LC₅₀ 1000000 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2019.

PEC = 0.9417 microg/L.

NEC = Lowest LC₅₀, 1000000 microg/L/1000 (Assessment Factor (AF) for 3 acute studies) = 1000 microg/L.

PEC/PNEC = 0.001 which gives the risk insignificant.

Author: Health and Medical Care Administration, Region Stockholm