Nelarabine
Summary
Persistence. Nelarabine is potentially persistent
Bioaccumulation. Nelarabine has low potential for bioaccumulation.
Toxicity. Nelarabine has low acute toxicity. See, however, the comment under "Detailed information".
Risk. The use of nelarabine (sales data Sweden 2018) has been considered to result in insignificant environmental risk.
This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Atriance (nelarabine) från Sandoz AS (retrieved on 2025-12-10).
Hazard
Persistence: For biotic degradation, no data are available for ready degradability. Inherent degradability shows 40 % ultimate degradation (DOC removal) in 14 days and 100 % primary degradation in 14 days according to OECD 302. Soil degradation amounts to 22.6–30.4 % in 64 days (TAD 3.12). In abiotic degradation via hydrolysis, the half‑life is 9.5 hours at pH 7, 21.3 days at pH 5, and 3.5 hours at pH 9, while no data are available for photolysis. Overall, Nelarabine is neither readily nor inherently degradable, and therefore the phrase "Nelarabine is potentially persistent" is applied.
Bioaccumulation: Log Pow < 1 (OECD 107).
Acute toxicity: There are data for 3 trophic levels, most sensitive algae IC50 > 100000 microg/L. Comment. Values reported as greater than are not according to the guidelines. The actual value may be lower.
Risk
PEC/PNEC is based on sales data in Sweden in year 2018.
PEC = 0.00000289 microg/L.
PNEC = Lowest IC50, 100000 microg/L/1000 (Assessment Factor (AF) for 3 acute studies) = 100 microg/L.
PEC/PNEC = 2.89 x 10-8 which gives the risk insignificant.
References
Author: Health and Medical Care Administration, Region Stockholm