Rizatriptan
Summary
Persistence. Rizatriptan is slowly degraded in the environment.
Bioaccumulation. Rizatriptan has low potential for bioaccumulation.
Toxicity. Rizatriptan has low chronic toxicity.
Risk. The use of rizatriptan (sales data Sweden 2023) has been considered to result in insignificant environmental risk.
This summary information for rizatriptan comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Maxalt (rizatriptan) from Organon Sweden AB (retrieved on 2026-04-22).
Hazard
Persistence: The degradation of rizatriptan was assessed in an OECD 308 study using aerobic water/sediment systems over 99 days. The results showed primary degradation with one major metabolite and overall DT50 values of 5.9–8.6 days for the total system. As more than 15% of the parent compound remained at the end of the study, the phrase The substance is slowly degraded in the environment is applied.
Bioaccumulation: Log Kow = -0.649 at pH 7 (OECD 107).
Toxicity: There are data for 3 trophic levels, most sensitive fish (Pimephales promelas) NOEC 9600 microg/L.
Risk
PEC/PNEC is based on sales data in Sweden in year 2023.
PEC = 0.0014 microg/L.
PNEC = Lowest NOEC, 9600 microg/L/10 (Assessment Factor (AF) for 3 chronic studies) = 960 microg/L.
PEC/PNEC = 1.46 x 10-6 which gives the risk insignificant.
References
Author: Health and Medical Care Administration, Region Stockholm