Teicoplanin
Summary
Persistence. Teicoplanin is considered to be potentially persistent.
Bioaccumulation. Teicoplanin has low potential for bioaccumulation.
Toxicity. Teicoplanin has moderate acute toxicity.
Risk. The use of teicoplanin (sales data Sweden 2023) has been considered to result in insignificant environmental risk.
This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Targocid (teicoplanin) from Sanofi AB ( (retrieved on 2026-04-13).
Excretion (metabolism)
"In 16 days, more than 80% of administered teicoplanin are excreted in urine as parent compound (Ref VII). Two metabolites (metabolites 1 and 2; 2 to 3% of total teicoplanin) have been isolated and their structures were found to be new teicoplanin-like molecules, bearing 8-hydroxydecanoic and 9-hydroxydecanoic acyl moieties, respectively."
Hazard
Persistence: "Test results showed 0% degradation in 28 days. Therefore, teicoplanin is considered to be potentially persistent."
Bioaccumulation: Log Kow of 0.8 (method/model: XLogP3-AA).
Toxicity: There are data for 3 trophic levels, most sensitive algae EC50 236 microg/L.
Risk
PEC/PNEC is based on sales data in Sweden in year 2023.
PEC = 0.00027 microg/L.
PNEC = Lowest EC50, 236 microg/L/1000 (Assessment Factor (AF) for 3 acute studies) = 0.236 microg/L.
PEC/PNEC = 0.00114 which gives the risk insignificant.
References
Author: Health and Medical Care Administration, Region Stockholm