Tioguanine
Summary
Persistence. Tioguanine is potentially persistent.
Bioaccumulation. Tioguanine has low potential for bioaccumulation.
Toxicity. Tioguanine has very high acute toxicity.
Risk. Risk of environmental impact of tioguanine cannot be excluded, since there is not sufficient ecotoxicity data available.
This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Lanvis (tioguanine) from Aspen Nordic (retrieved on 2026-01-20).
Hazard
Persistence: Biodegradation: 5% in 28 days (ready), 68% in 28 days (inherent). The medicine is considered potentially persistent. Abiotic degradation: Hydrolysis with a half‑life of 62 days at pH 7.
Bioaccumulation: Log Kow = - 0.07.
Toxicity: There are data for 2 trophic levels, most sensitive green algae EC50 3,4 microg/L.
Risk
PEC/PNEC is based on sales data in Sweden in year 2024.
PEC = 1.50 10-4 microg/L.
Risk of environmental impact of tioguanine cannot be excluded, since there is not sufficient ecotoxicity data available.
References
Author: Health and Medical Care Administration, Region Stockholm