Hazard 3 P 3 B 0 T 0 Risk Insignificant
The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B, T and risk are from Fass.
Fass environmental information for Zovirax (downloaded 2019-01-24).
Persistence: "Biotic degradation. Ready degradability: 0.7% degradation in 28 days (TAD 3.11). Inherent degradability: 100% primary (loss of parent) degradation in 14 days (OECD 302B).
Abiotic degradation. Hydrolysis: Half-life, pH 7 > 1 year (TAD 3.09). Photolysis: Half-life, pH 7 = 3.5 hours (TAD 3.10).
Aciclovir is not readily biodegradable nor inherently biodegradable. The phrase “Aciclovir is potentially persistent” is thus chosen."
Bioaccumulation: "Log Pcalc = -1.55. (Chemaxon)."
Toxicity: There are data for 3 trophic levels, most sensitive crustacean (Ceriodaphnia dubia) NOEC 10 000 microg/L.
PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.0012 which gives the risk insignificant.
Author: Health and Medical Care Administration, Region Stockholm