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Aciclovir

Hazard 3 P 3 B 0 T 0 Risk Insignificant

Information

The T-value in the score for hazard refers to chronic toxicity. Underlying data for P, B, T and risk are from Fass.

Fass environmental information

Fass environmental information for Zovirax (downloaded 2019-01-24).

Hazard

Persistence: "Biotic degradation. Ready degradability: 0.7% degradation in 28 days (TAD 3.11). Inherent degradability: 100% primary (loss of parent) degradation in 14 days (OECD 302B).

Abiotic degradation. Hydrolysis: Half-life, pH 7 > 1 year (TAD 3.09). Photolysis: Half-life, pH 7 = 3.5 hours (TAD 3.10).

Aciclovir is not readily biodegradable nor inherently biodegradable. The phrase “Aciclovir is potentially persistent” is thus chosen."

Bioaccumulation: "Log Pcalc = -1.55. (Chemaxon)."

Toxicity: There are data for 3 trophic levels, most sensitive crustacean (Ceriodaphnia dubia) NOEC 10 000 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2016. PEC/PNEC = 0.0012 which gives the risk insignificant.

Author: Health and Medical Care Administration, Region Stockholm