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Pharmaceuticals and Environment

Here you can find information about the environmental impact of pharmaceuticals. You can search for the substance name. Unless otherwise stated, the environmental impact means impact of pharmaceuticals when used.

Information about the classification

In the document there is information about the classification of the environmental hazard and the environmental risk. The text may indicate if T refers to acute or chronic toxicity. The environmental hazard is classified from 0–9, where a high number indicates high properties for making an environmental impact. The classification of the risk is usually based on theoretical calculations of the risk. For more information see Classification.

For some substances there is also a risk assessment made on the basis of concentrations measured in the environment in Sweden and efficacy studies with high quality. These assessments are presented in the documents for the substances and are made by independent ecotoxicological expertise. Continuous work is underway to provide more substance documents with this type of environmental information and also present comparisons of environmental risk between substances intended for the same indication. Based on this type of risk assessment, a table of environmentally hazardous drugs has been developed within the framework of Stockholm County Council's environmental program 2017–2021.

News

Bengtsson-Palme J, Milakovic M, Švecová H, et al. Industrial wastewater treatment plant enriches antibiotic resistance genes and alters the structure of microbial communities. Water Res. 2019 Oct 1;162:437-445. doi: 10.1016/j.watres.2019.06.073.
2019-08-12

Khan FA, Söderquist B, Jass J. Prevalence and Diversity of Antibiotic Resistance Genes in Swedish Aquatic Environments Impacted by Household and Hospital Wastewater.
Front. Microbiol., 04 April 2019

Consumption of antibiotics and occurrence of antibiotic resistance in Sweden
Public Health Agency of Sweden and National Veterinary Institute
2019-06-11

New database for pharmaceutical in the environment initiatives
Safer Pharma
2019-05-01

New report calls for urgent action to avert antimicrobial resistance crisis
WHO
2019-04-29

Pribis JP, García-Villada L, Zhai Y, et al. Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response. Molecular Cell. Available online 1 April 2019. https://doi.org/10.1016/j.molcel.2019.02.037

European Union Strategic Approach to Pharmaceuticals in the Environment
European Commission
2019-03-11

The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2017
EFSA Journal 2019;17(2):5598.
2019-02-26

Oldenkamp R, Beusen AHW and Huijbregts MAJ.Aquatic risks from human pharmaceuticals—modelling temporal trends of carbamazepine and ciprofloxacin at the global scale. Environ. Res. Lett. 14 (2019) 034003.
2019-02-22

Nicoloff H, Hjort K, Levin BR, Andersson DI. The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification
Nat Microbiol. 2019 Feb 11. doi: 10.1038/s41564-018-0342-0.
2019-02-11

The Infectious Diseases Society of America’s 10 × ’20 Initiative (Ten New Systemic Antibacterial Agents FDA-approved by 2020): Is 20 × ’20 a Possibility?
Clinical Infectious Diseases
2019-02-01

Pharmaceutical industry lacks a clear and transparent commitment to environmental protection
Health Care Without Harm
2019-01-28

Revised guideline aims to strengthen global approach to development of new antibacterial medicines
European Medicines Agency
2019-01-14

New hope to rescue the livesaving antibiotics
SIWI Stockholm International Water Institute
2019-01-10

Karkman, A., K. Pärnänen, and D.G.J. Larsson. Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments.
Nature Communications, 2019. 10(1): p. 80.
2019-01-08

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