Alimemazine
Summary
Persistence. Alimemazine is potentially persistent.
Bioaccumulation. Conflicting data exist regarding the potential of alimemazine to bioaccumulate.
Toxicity. Alimemazine has very high acute toxicity.
Risk. Risk of environmental impact of alimemazine cannot be excluded, since there is not sufficient ecotoxicity data available.
This summary information comes from the report by Goodpoint. Environmental information is missing on fass.se for alimemazine (2024-06-18).
Detailed information
Report from Goodpoint on comparisons with diazepam and oxazepam
Alimemazine has not been studied in the environment, effect studies of alimemazine are very insufficient and there are contradictory fat solubility data for alimemazine. However, the limited data available suggests that effects in the environment of alimemazine are fully possible, but further investigation of alimemazine fat solubility should be done.
Estimated fat solubility (log POW) for alimemazine is 5.0 according to Schultz and Smoldt, and estimated log P values between 4.41 and 4.82 are reported in Drugbank indicating a very high ability to bioconcentrate in biota. Sanofi, on the other hand, reports a much, much lower, experimental log P of -0.43 in Fass.se.
Use of oxazepam has been estimated to pose a risk of environmental impact based on measured concentrations in Swedish surface water and in Swedish wild fish. These concentrations are very close to those that affect the behavior of fish. Diazepam is metabolised to some extent to oxazepam and may therefore contribute to this risk. At present, it is not recommended to replace oxazepam or diazepam with alimemazine without a prior investigation into the fat solubility of alimemazine.
Author: Health and Medical Care Administration, Region Stockholm