Persistence. Allopurinol is potentially persistent.
Bioaccumulation. Allopurinol has low potential for bioaccumulation.
Toxicity. Allopurinol has very high acute toxicity.
Risk. The use of allopurinol (sales data Sweden 2021) has been considered to result in moderate environmental risk.
This summary information comes from Fass.
Fass environmental information
Fass environmental information for Zyloric (allopurinol) from Aspen Nordic (downloaded 2023-04-13).
Persistence: Inherent biodegradation: Test result 2 % degradation in 28 days ( Modified Zahn-Wellens - OECD 302B). ... The medicine is potentially persistent.
Bioaccumulation: Log Pow = 0.32 ... This material is not likely to sorb to soil or sediment. Measured soil sorption coefficient, log Koc is < 1.25. (OECD 121).
Acute toxicity: There are data for 3 trophic levels, most sensitive algea EC50 72h = 450 microg/L (OECD 201).
PEC/PNEC is based on sales data in Sweden in year 2021. PEC/PNEC = 1.86 which gives the risk moderate.
Author: Health and Medical Care Administration, Region Stockholm