This summary information comes from Fass.
Persistence. Amidotrizoate meglumine/sodium salt is potentially persistent.
Bioaccumulation. Amidotrizoate meglumine/sodium salt” has a low potential for bioaccumulation.
Toxicity. Amidotrizoate meglumine salt has moderate acute toxicity.
Risk. Risk of environmental impact of amidotrizoate meglumine/sodium salt” cannot be excluded, since there is not sufficient data available.
Fass environmental information
Fass environmental information for Gastrografin (amidotrizoic acid) from Bayer (downloaded 2021-11-12).
Persistence: "The test compound (meglumin salt of amidotrizoate) was studied for ready biodegradability in a test conducted over 28 days in the modified OECD screening test (OECD 301E) (5). The observed degradation did not exceed 19% (day 3). Specific analytical measurements of the parent compound (megluminamidotrizoate) showed that the amount of the compound did not decrease over time. Therefore, it is likely that the meglumin fraction of the molecule accounted for the observed degradation."
Bioaccumulation: "The octanol/water partition coefficient of megluminamidotrizoate was determined with -4.09, using a shake-flask method at 25 degrees Celsius and 24h shaking."
Toxicity: There are data for 2 trophic levels, most sensitive crustacean (Daphnia magna) "EC50 /48 h (immobilization) = >100 mg/L (guideline OECD 202)." Comment: Values reported as greater than are not according to the guidelines. The actual value may be lower.
Risk of environmental impact of amidotrizoate meglumine/sodium salt” cannot be excluded, since there is not
sufficient data available.
EU list of groundwater monitoring and candidates
Amidotrizoic acid is on the EU's watchlist of substances whose concentrations in groundwater should be monitored in the Member States for environmental reasons.
Author: Health and Medical Care Administration, Region Stockholm