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Persistence. Amiodarone is potentially persistent.

Bioaccumulation. Amiodarone has high potential for bioaccumulation.

Toxicity. Amiodarone has high chronic toxicity.

Risk. The use of amiodarone (sales data Sweden 2021) has been considered to result in insignificant environmental risk.


This summary information comes from Fass.

Fass environmental information

Fass environmental information for Cordarone (amiodarone) from Sanofi AB (downloaded 2023-10-04).


Persistence: "Test showed 0% degradation in 28 days (OECD 301B). Amiodarone fails to pass the criteria for ready biodegradability which justifies the phrase “Amiodarone is potentially persistent”."

Bioaccumulation: Log Pow = 7.96 (Protocol: OECD 123).

Chronic toxicity: There are data for 3 trophic levels, most sensitive algae (Pseudokirchneriella subcapitata) NOEC 72 hours = 12 microg/L.


PEC/PNEC is based on sales data in Sweden in year 2021. PEC / PNEC = 0.044 which gives the risk insignificant.

Pharmaceutical analyses of water in Sweden

Amiodarone has been analysed but not detected in treated wastewater, surface water and drinking water in Region Stockholm during recent measurements. Amiodarone has previously been detected in the Stockholm area and was included in national screening programs but was then below the detection limits.

Author: Health and Medical Care Administration, Region Stockholm