Persistence. It cannot be excluded that amitriptyline is persistent, due to the lack of data.
Bioaccumulation. Amitriptyline has a high potential to bioaccumulate.
Toxicity. It cannot be excluded that amitriptyline is toxic, due to the lack of data.
Risk. Risk of environmental impact of amitriptyline cannot be excluded, due to the lack of environmental toxicity data.
This summary information comes from Fass. It is voluntary for manufacturers to provide information on environmental impact on fass.se.
Amitriptyline's major metabolite is nortriptyline. See also nortriptyline.
Fass environmental information
Fass environmental information for Amitriptylin Abcur from Abcur (downloaded 2022-12-21).
Persistence: No data.
Bioaccumulation: Log Kow = 4.92 (unknown method).
Toxicity: No data.
Risk of environmental impact of amitriptyline cannot be excluded, since no ecotoxicity data are available.
Pharmaceutical analyses of water in Region Stockholm and nationally in Sweden
Amitriptyline has been found in treated wastewater (up to 24 ng/L), surface water (up to 9.1 ng/L) and sludge (up to 170 microg/kg dry weight) at national measurements. The IVL report also presents results from regional screening programs. Region Stockholm analyzes for amitriptyline.
Amitriptyline in spiders
Amitriptyline has been detected in spiders (article Richmond et al. 2018).
- Fass.se för vårdpersonal.
- IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
- Provtagningar av läkemedelsrester i vatten, sediment och fisk för Region Stockholm.
- Richmond EK, Rosi EJ, Walters DM, Fick J, Hamilton SK, Brodin T et al. A diverse suite of pharmaceuticals contaminates stream and riparian food webs. Nat Commun. 2018;9(1):4491.
Author: Health and Medical Care Administration, Region Stockholm