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Hazard - P - B 3 T - Risk Cannot be excluded

Underlying information about P, ​​B, T and risk comes from Fass. Amitriptyline's major metabolite is nortriptyline. See also nortriptyline.

Fass environmental information

Fass environmental information for Amitriptylin Abcur (downloaded 2018-11-06).


Persistence: No data.

Bioaccumulation: Log Kow = 4.92 (unknown method).

Toxicity: No data.


Risk of environmental impact of amitriptyline cannot be excluded, since no ecotoxicity data are available.

Pharmaceutical analyses of water in Stockholm County and nationally in Sweden

Amitriptyline has been found in treated wastewater (up to 24 ng/L), surface water (up to 9.1 ng/L) and sludge (up to 170 microg/kg dry weight) at national measurements. The IVL report also presents results from regional screening programs. Amitriptyline has been found in treated wastewater (over 20 ng/L) in Stockholm County during the last five-year period (2012-2016).

Author: Health and Medical Care Administration, Region Stockholm