Artemether
Summary
Persistence. Artemether is potentially persistent.
Bioaccumulation. Artemether has high potential for bioaccumulation.
Toxicity. Artemether has very high acute toxicity.
Risk. The use of artemether (sales data Sweden 2022) has been considered to result in insignificant environmental risk.
This summary information comes from Fass.
Detailed information
Fass environmental information
Fass environmental information Riamet (artemether, lumefantrine) for artemether (downloaded 2024-07-03)
Hazard
Persistence: "8.0 % degradation in 28 days, not readily biodegradable (OECD302C). Artemether does not pass the criteria for ready biodegradation."
Bioaccumulation: Log Pow = 4.4.
Acute toxicity: There is data for 3 trophic levels, lowest for algae (Selenastrum capricornutum) 0.33 mg/L.
PBT/vPvB assessment
"As no chronic environmental toxicity data is available no definitive assessment of the T criteria can be made. Toxicity to aquatic species has been found in acute toxicity studies, but cannot be used to assess the PBT criteria."
Risk
PEC/PNEC is based on sales data in Sweden in year 2022. PEC/PNEC = 0.000042 which gives the environmental risk insignificant.
References
Author: Health and Medical Care Administration, Region Stockholm