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Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal

Atenolol

Summary

Hazard - P - B 0 T - Risk See below

 

Underlying data for P, B and T are from Fass.

Fass environmental information

Fass environmental information for Atenolol Takeda from Takeda Pharma (downloaded 2019-07-09).

Hazard

Persistence: No data.

Bioaccumulation: "Log Pow = 0,16 (method used: Calculation of octanol-water coefficient by fragments using the
CLOGP Software). Since log Pow < 4, the substance has low potential for bioaccumulation."

Toxicity: No data.

Risk

Risk of environmental impact of atenolol cannot be excluded, since there is not sufficient ecotoxicity data
available.

Pharmaceuticals in the aquatic environment in Stockholm Region

Atenolol has been detected in treated wastewater and surface water in Region Stockholm in 2018.

Report Goodpoint 2016

Atenolol is well researched in terms of the environmental hazard and measured concentrations in the environment in Sweden. On this basis, the safety margin for environmental impact is assessed to be good.

References

  1. Fass.se för vårdpersonal
  2. Provtagningar av läkemedelsrester i vatten, sediment och fisk för Region Stockholm
  3. Goodpoint. Prioritering av läkemedel med miljörisk inom SLL. Stockholm: Goodpoint; 2016. Rapport LS 2016–0634.
  4. Winter MJ, Lillicrap AD, Caunter JE, Schaffner C, Alder AC, Ramil M et al. Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas). Aquat Toxicol. 2008;86:361-9.
  5. IVL Swedish Environmental Research Institute Ltd Fick J, Lindberg RH, Fång J, Magnér J, Kaj L, Brorström-Lundén E. Screening 2014. Analysis of pharmaceuticals and hormones in samples from WWTPs and receiving waters. Rapport C 135.
  6. IVL Swedish Environmental Research Institute Ltd. Fick J, Lindberg RH, Kaj L, Brorström-Lundén E. Results from the Swedish National Screening Programme 2010. Subreport 3, B 2014 Pharmaceuticals.
  7. Fick J, Lindberg RH, Tysklind M, Larsson DG. Predicted critical environmental concentrations for 500 pharmaceuticals. Regul Toxicol Pharmacol. 2010;58:516-23.

Author: Health and Medical Care Administration, Region Stockholm