Atovaquone
Summary
Persistence. The potential for persistence of atovaquone cannot be excluded, due to lack of data.
Bioaccumulation. Atovaquone has high potential for bioaccumulation.
Toxicity. Atovaquone has very high chronic toxicity.
Risk. Risk of environmental impact of atovaquone cannot be excluded, since there is not sufficient ecotoxicity data available.
This summary information comes from Fass.
Detailed information
Fass environmental information
Fass environmental information for atovaquone, Malarone Junior (atovaquone, proguanil) (downloaded 2024-07-03).
Hazard
Persistence: "Atovaquone is rapidly degraded in soil, the compartment to which it is likely to partition. For the terrestrial compartment the phrase ‘atovaquone is degraded in the environment’ is appropriate. However, for the aquatic compartment the phrase “The potential for persistence of Atovaquone cannot be excluded, due to lack of data” is thus chosen."
Bioaccumulation: Log Kow = 5.31 at pH 7.
Chronic toxicity: There are data for 1 trophic level. NOEC for 8 days crustacean (Ceriodaphnia dubia) 0.083 microg/L.
PBT/vPvB assessment
"The appropriate degradation data are not available to assign PBT/vPvB criteria."
Risk
"Risk of environmental impact of atovaquone cannot be excluded, since there is not sufficient ecotoxicity data available."
References
Author: Health and Medical Care Administration, Region Stockholm