Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal

Azelaic acid

Summary

Persistence. It cannot be excluded that azelaic acid is persistent, due to the lack of data.
Bioaccumulation. It cannot be excluded that azelaic acid bioaccumulates, due to the lack of data.
Toxicity. It cannot be excluded that azelaic acid is toxic, due to the lack of data.
Risk. For azelaic acid there is nothing that indicates an environmental hazard.

Environmental information is missing on fass.se for azelaic acid (2022-06-30). It is voluntary for manufacturers to provide information on environmental impact on fass.se.

Detailed information

Report Goodpoint 2018

Comparative assessment of environmental risk and risk of resistance selection in human use of ivermectin, metronidazole, lymecycline and azelaic acid in Sweden.

The risk is clearly highest for lymecycline based on measured concentrations of tetracycline in uncleaned waste water that exceeds experimental established selective levels for antibiotic resistance in bacteria. A similar but lower risk profile exists for metronidazole based on total use but with significantly lower empirical support for the efficacy The topical use of metronidazole results in a negligible risk of resistance selection in waste water treatment plants. The risk of effects of human use of ivermectin is also low, given an expected contribution to exposure in aquatic environments at subnanogram levels, and a majority of efficacy studies that show significantly higher levels of efficacy. Since there is (at least) a study that reports effects at 1 pg/L, however, one can not completely rule out risk. For azelaic acid there is nothing that indicates an environmental hazard.

Author: Health and Medical Care Administration, Region Stockholm