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Benserazide

Summary

Persistence. Benserazide is not considered to be persistent.

Bioaccumulation. Benserazide has low potential for bioaccumulation.

Toxicity. Benserazide has high acute toxicity.

Risk. The use of benserazide (sales data Sweden 2021) has been considered to result in insignificant environmental risk.

 

With the exception of persistence, this summary information comes from Fass. Based on Fass's environmental information, benserazide is not considered to be persistent according to an expert (Researchers at the Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University 2018-12-05).

Fass environmental information

Fass environmental information for benserazide from Madopark (benserazide, levodopa) from Roche (downloaded 2023-02-06).

Hazard

Persistence: "Biotic Degradation - Ready biodegradability: 2% after 28 days of incubation BOD/ThOD (OECD 301 F), 48% after 28 days of incubation DOC/TOC (OECD 301 F), 100% after 28 days of incubation Parent (OECD 301 F). Inherent biodegradability: 84% after 7 days of incubation DOC (OECD 302 B), 93% after 14 days of incubation DOC (OECD 302 B), 93% after 28 days of incubation DOC (OECD 302 B). Other degradation information: ND. Abiotic Degradation - Photodegradation: 58% (120 h, 22 °C, light), Hydrolysis: 52% (120 h, 22 °C, in the dark). Benserazide is not readily degradable, but inherently biodegradable according to OECD 302 B. This justifies the phrase 'Benserazide hydrochloride is slowly degraded in the environment."

Bioaccumulation: log Kow ≤ 0.5 QSAR benserazide, BCF < 10 QSAR benserazide.

Acute toxicity: There is data for 3 trophic levels, lowest for green alga (Desmodesmus subspicatus) ErC50 72 h (growth rate) = 2 660 microg/L.

Risk

PEC/PNEC is based on sales data in Sweden in year 2021. PEC/PNEC = 0.019 which gives the risk insignificant.

Assessment of persistence according to expert

Based on Fass's environmental information above, benserazide is not considered to be persistent according to expert (Researcher at the Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University 2018-12-05).

References

  1. Fass.se för vårdpersonal.

Author: Health and Medical Care Administration, Region Stockholm