Gå till innehåll

Kommersiellt obunden läkemedelsinformation riktad till läkare och sjukvårdspersonal



This summary information comes from Fass.


Persistence. Bisoprolol is degraded in the environment.
Bioaccumulation. Bisoprolol has low potential for bioaccumulation.
Toxicity. Bisoprolol has low chronic toxicity.
Risk. The use of bisoprolol (sales data Sweden 2018) has been considered to result in insignificant environmental risk.

Detailed information

Fass environmental information

Fass environmental information for Emconcor (bisoprolol) from Merck (downloaded 2021-07-06).


Persistence: DT50 in water: 3.7 and 8.4 days. DT50 total system: 8.6 and 27.7 days. Since the DT50 is ≤ 32d in both systems and there is <15% remaining parent compound at the end of the 50 study in both systems (approx. 5% for Dausenau and approx. 10% for Burgen) the phrase “The substance is degraded in the environment” is chosen.

Bioaccumulation: Log Kow = -0.86 at pH 7 (guideline OECD 107).

Toxicity: There are data for 3 trophic levels, most sensitive algae (Desmodesmus subspicatus) NOEC = 1.78 mg/L.


PEC/PNEC is based on sales data in Sweden in year 2018. PEC/PNEC = 0.0003 which gives the risk insignificant.

Pharmaceuticals residues in the aquatic environment in Sweden

Bisoprolol has been measured in effluent from wastewater treamtent plants up to 96 ng/L and in surface water up to 34 ng/L in Sweden. Results from regional sampling programs in Sweden are also reported in IVL's report from 2014.

Author: Health and Medical Care Administration, Region Stockholm