Underlying data for P, B, T and risk are from Fass.
Fass environmental information for Pravidel (bromocriptine) (downloaded 2018-10-31).
Persistence: No data.
Bioaccumulation: "A computed Log P of 3,8 (XLogP3) indicates that bromocriptine has low potential for bioaccumulation. Log P < 4 which justifies the phrase “Bromocriptine has low potential for bioaccumulation”."
Toxicity: No data.
"According to the European Medicines Agency guideline on environmental risk assessment of medicinal products (EMA/CHMP/SWP/4447/00), use of bromocriptine is unlikely to represent a risk for the environment, because the predicted environmental concentration (PEC) is below the action limit 0,01 μg/L. Risk för miljöpåverkan av bromokriptin kan inte uteslutas då ekotoxikologiska data saknas."
Bromocriptine has been found in sludge (6.3 microg/kg) and treated wastewater (5.6 ng/L) at Swedish national measurements in 2010 but not 2014. The reduction rate has been set between 55 and 75 percent. Bromocriptine has been below the LOQ (limit of quantification) in measurements of treated wastewater within the Stockholm region 2012-2016, as well as in measurements 2017 of treated wastewater, surface water and drinking water. In the report on drug residues in the Stockholm aquatic environment, bromocriptine has been found in treated wastewater from Henriksdal wastewater treatment plant and in sludge from the same wastewater treatment plant.
Author: The Pharmaceutical unit of Region Stockholm