Cabazitaxel
Summary
Persistence. Cabazitaxel is potentially persistent.
Bioaccumulation. Cabazitaxel has low potential for bioaccumulation.
Toxicity. Cabazitaxel has very high chronic toxicity.
Risk. The use of cabazitaxel (sales data Sweden 2015) has been considered to result in insignificant environmental risk.
This summary information comes from fass.se.
Detailed information
Fass environmental information
Fass environmental information for Jevtana (cabazitaxel) (downloaded 2018-06-26).
Hazard
Persistence: Test showed 17.76 % degradation in 28 days (guideline OECD 301B).
Bioaccumulation: Log Pow = 3.78 at pH 7 (guideline OECD 107).
Chronic toxicity: There is NOEC for 3 trophic levels, lowest NOEC 21 days for crustacean (Daphnia magna) 8.9 microg/L.
Risk
PEC/PNEC is based on sales data in Sweden in year 2015. PEC/PNEC = 0.00000843, which gives the risk insignificant.
References
Author: Health and Medical Care Administration, Region Stockholm